the increase in developed countries, bedbug bites and related conditions have been on the rise as well, since the 1980s-1990s. The exact causes of this resurgence remain unclear; it is variously ascribed to greater foreign travel, more frequent exchange of second-hand furnishings among homes,Bedbug bites or cimicosis may lead to a range of skin manifestations from no visible effects to prominent blisters. 446 Diagnosis involves both finding bedbugs and the occurrence of compatible symptoms. ranging from no visible effect (in about 20-70%) to small macular spots, prominent wheals and bullae formation along with intense itching that may last several days. A central hemorrhagic spot may also occur due to the release of anticoagulants in the saliva.
Symptoms may not appear until some days after the bites have occurred. Reactions often become more brisk after multiple bites due to possible sensitization to the salivary proteins of the bedbug. The skin reaction usually occurs in the area of the bite which is most commonly the arms, shoulders and legs as they are more frequently exposed at night.Other possible conditions with which these conditions can be confused include: scabies, allergic reactions, mosquito bites, spider bites, chicken pox and bacterial skin infections. Bed bugs classically form a line of bites colloquially referred to as "breakfast, lunch, and dinner" and rarely feed in the armpit or behind the knee which may help differentiate it from other biting insects.
